Diflucan microbiological properties and metabolism

The main component in Diflucan - Fluconazole selectively works for fungal cytochrome P450 dependent enzyme lanosterol 14-α-demethylase. The medicine stops the transformation of lanosterol to ergosterol induced by fungal cytochrome enzyme.

Diflucan has demonstrated high activity against the following fungi:

 Candida albicans

 Candida glabrata

 Candida parapsilosis

 Candida tropicalis

 Cryptococcus neoformans

Fluconazole may also be used as a therapy for the following microorganisms though its efficacy has not been proven by the clinical experience:

 Candida dubliniensis

 Candida guilliermondii

 Candida kefyr

 Candida lusitaniae

Other types of Candida (especially superinfections) are considered to be resistant to the action of fluconazole. However in some cases this medicine may be observed as an adjunct or alternative therapy for certain conditions (superinfections) caused by Candida.

Diflucan Metabolism

Diflucan for oral use has shown max plasma concentrations within 1-2 hours post oral administration. Plasma concentrations of the drug are dose-propotional. The half-life of the medicine ranges from 20 up to 50 hours.

The food does not affect the rate of absorption of the drug. The medicine can be used with or without food.

The persistent concentrations of the medicine are obtained within 5–10 days using the single oral doses of 50–400 mg.

Diflucan plasma protein binding is about 11–12%. The medicine easily penetrates into skin, saliva, cerebrospinal fluid, sputum, urine, vaginal tissue and in vaginal fluid.

The medicine is cleared by kidneys. The elimination of 80% of the drug is in the urine. Patients with kidney disorders may have reduced rate of clearance of the medicine. They should receive only half of the normal dose of the medicine.

Diflucan indications

Diflucan (fluconazole) has the following directions of use: The main purpose of use of Diflucan – treatment of infections caused by candida -Vaginal candidiasis.diflucan Urinary tract infections caused by candida. Peritonitis caused by candida. Systemic candida infections such as candidemia, pneumonia, disseminated candidiasis. Oropharyngeal and esophageal candidiasis. As a preventative or prophylactic method to reduce the risk of candidiasis in patients who have transplantation of the bone marrow or radiation therapy, or chemotherapy. Cryptococcal  meningitis in AIDS patients. Diflucan is not used in patients who have increased sensitivity to fluconazole.

About results

iCAX068PNMy husband had to have oral surgery, and took Diflucan for 2 weeks. He got the generic fluconazole,this drug prescribed him his dentist. One year ago he used Diflucan and had great success. He thinks that the generic Diflucan does NOT work as well as the name brand. 3 days and 3  pills later, but he is still suffering with the yeast infection symptoms.

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